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Md. Fazlul Karim, PhD

মোঃ ফজলুল করিম, পিএইচডি
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About Me

I have had the privilege of developing a strong background in Biotechnology and Genetic Engineering, with extensive experience in both teaching and research. Throughout my career, I have focused on molecular biology, proteomics, and cell signalling, making significant advancements in understanding and addressing metabolic disorders such as cancer, liver diseases, diabetes, and osteoporosis.
Over the years, I have progressed through several academic ranks, from lecturer to professor, and have gained international experience as an Assistant Professor at Kumamoto University in Japan. This experience greatly enriched my teaching and research skills while broadening my global scientific perspective. I also had the honour of serving as the Director of the Research Cell at Mawlana Bhashani Science and Technology University. During this time, I led research initiatives, secured research grants, and mentored faculty and students, contributing to the enhancement of the university's research profile.
My research primarily focuses on investigating the molecular mechanisms of diseases, particularly protein-protein interactions and post-translational modifications in cell signalling pathways. I have had the opportunity to publish my work in prestigious peer-reviewed journals, including Nature Communications (Impact Factor: 15.7) and Cell Metabolism (Impact Factor: 30.9), with a total of 700 plus citations, an h-index of 10, and an i10-index of 10. These milestones reflect the impact my research has had in the field of biotechnology.
In addition to my academic work, I have been fortunate to receive numerous prestigious national and international research grants and fellowships. I remain deeply committed to advancing academic excellence, mentoring the next generation of scientists, and developing innovative solutions to address critical health challenges. My leadership, passion for biotechnology, and dedication to research continue to drive my ongoing efforts to make meaningful contributions to the field.

Research Interest

1. Molecular Biology

2. Proteomics

3. Cell Signaling

4. Metabolic Disorders (Cancer, Liver Diseases, Diabetes, Osteoporosis)

Professional & Other Experiences

Professional Experience (National)
1. 15 April 2022 – Present
Professor, Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Tangail, Bangladesh

2. 25 May 2014 – 14 April 2022
Associate Professor, Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Tangail, Bangladesh

3. 22 February 2009 – 24 May 2014
Assistant Professor, Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Tangail, Bangladesh

4. 22 February 2006 – 22 February 2009
Lecturer, Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Tangail, Bangladesh

Professional Experience (International)
1. 20 February 2019 – 31 January 2021
Post-Doctoral Fellowship, Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, PA, USA

2. 1 September 2014 – 31 July 2018
Assistant Professor, Department of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, Japan

Leadership and Administrative Experience
1. Currently working
Director, Student Welfare and Counseling Center, MBSTU

2. 12 August 2021 – 11 August 2023
Director, Research Cell, MBSTU

3. 01 May 2014 – 15 August 2014
Chairman, Department of Biotechnology and Genetic Engineering, MBSTU

4. 26 August 2007 – 10 October 2008
Assistant Exam Controller (In-charge), MBSTU

5. June 2006 – May 2007
Joint Secretary, MBSTU Teachers Association

Education

1. Ph.D. in Medical Sciences, Kumamoto University, Japan, 2013
Dissertation: "Regulation of Cellular Metabolism by Nuclear Proteins"

2. Master’s in Biochemistry and Molecular Biology (1st class 6th), University of Dhaka, Bangladesh, 2005
oThesis: "Insulin Secretion, Insulin Sensitivity and Body Iron Stores in Type 2 Diabetic Subjects"

3. Bachelor’s in Biochemistry and Molecular Biology (1st class 5th), University of Dhaka, Bangladesh, 2003

4. HSC (Science) (1st Division), Dhaka College, Dhaka board, 1996

5. SSC(Science) (1st Division), Santipur Adarsha High School, Dhaka board, 1994

Publications

1.Hashim ZM, Fakree NK, Al-Juboori AAA, Karim MF, Radhi ZM, Amin SS, Alkutbi SH, Ibrahim ZI, Hassan EA, Khalaf ZA, Al-Gburi H, Nassir ES, Ferdoushi A. Association between maternal vitamin D, calcium, and inflammatory cytokines in Iraqi pregnant women with placental calcification. Pharmacia 2025 2.Sharfaraz A, Ferdoushi A, Hossain MA, Nupur AS, Salma U, Karim MF*. Computer-based discovery of SIRT7 inhibitors from Nigella sativa for cancer treatment. J Mol Graph Model 2025. *Corresponding author 3.Karim MF & Kabir Y. Role of histone modifications in the progression of cancer. Handbook of Cancer and Immunology, Springer Nature 2023. 4.Yoshizawa T, Sato Y, Sobuz SU, Mizumoto T, Tsuyama T, Karim MF, Bober E, Auwerx J, Yamagata K. SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice. Nat Commun. 2022. 5.Sobuz SU, Sato Y, Yoshizawa T, Karim MF, Ono K, Sawa T, Miyamoto Y, Oka M, Yamagata K. SIRT7 regulates the nuclear export of NF-κB p65 by deacetylating Ran. Biochim Biophys Acta Mol Cell Res. 2019. 6.Fukuda M*, Yoshizawa T*, Karim MF*, Sobuz SU, Korogi W,…Mizuta H, Yamagata K. SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix. Nat Commun. 2018. *Contributed equally 7.Korogi W, Yoshizawa T, Karim MF, Tanoue H, Yugami M, Sobuz SU, Hinoi E, Sato Y, Oike Y, Mizuta H, Yamagata K. SIRT7 is an important regulator of cartilage homeostasis and osteoarthritis development. Biochem Biophys Res Commun. 2018. 8.Karim MF, Yoshizawa T, Sobuz SU, Sato Y, Yamagata K. Sirtuin 7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4. Biochem Biophys Res Commun. 2017. 9.Sato Y, Tsuyama T, Sato C, Karim MF, Yoshizawa T, Inoue M, Yamagata K. Hypoxia reduces HNF4α/MODY1 protein expression in pancreatic β-cells by activating AMP-activated protein kinase. J Biol Chem. 2017. 10.Yamagata K, Karim MF, Sato Y, Yoshizawa T. Role of SIRT7 in hepatic lipid metabolism. Diabetol Int. 2015. 11.Yoshizawa T, Karim MF, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Takeya M, Tomizawa K, Ando Y, Araki E, Akaike T, Braun T, Oike Y, Bober E, Yamagata K. Sirt7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway. Cell Metab. 2014. 12.Ohki T, Utsu Y, Morita S, Karim MF, Sato Y, Yoshizawa T, Yamamura K, Yamada K, Kasayama S, Yamagata K. Low serum level of high-sensitivity C-reactive protein in a Japanese subject with MODY3. J Diabetes Invest. 2014. 13.Karim MF, Yoshizawa T, Sato Y, Sawa T, Tomizawa K, Akaike T, Yamagata K. Inhibition of H3K18 deacetylation of Sirt7 by Myb-binding protein 1a (Mybbp1a). Biochem Biophys Res Commun. 2013. 14.Sato Y*, Hatta M*, Karim MF*, Sawa T, Wei FY, Sato S, Magnuson MA, Gonzalez FJ, Tomizawa K, Akaike T, Yoshizawa T, Yamagata K. Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells. J Biol Chem. 2012. *Contributed equally 15.Karim MF, Akhter A, Pervin F, Kabir Y, Ali L. Insulin Secretion, Insulin Sensitivity and Body Iron Stores in Type 2 Diabetic Subjects. Diab Endocr J 2006.